E64
نویسندگان
چکیده
منابع مشابه
Site Directed Mutagenes of COX17 Residues, K46, F50, Y61, and E64
This research was performed to determine which amino acid residues were responsible for Cox17 copper binding. Cox17 mutants were transformed and expressed in yeast cells. Site directed mutagens of Cox17 occurred at positions 46 (K), 50 (F), 61(Y), and 64 (E). These mutants were not observed to interfere with copper binding.
متن کاملE64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions.
A number of epoxysuccinyl amino acid benzyl esters (HO-Eps-AA-OBzl) and benzyl amides (HO-Eps-AA-NHBzl) (where AA represents amino acid) were synthesized as analogues of E64, a naturally occurring inhibitor of cysteine proteinases. These inhibitors were designed to evaluate if selectivity for cathepsin B could be achieved by varying the amino acid on the basis of known substrate specificity. Co...
متن کاملResistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.
Cysteine proteinases (CPs) have been considered suitable targets for the development of antiparasitic drugs. To assess the importance of CPs for the growth and pathogenicity of the protozoan parasite Entamoeba histolytica we have cultured amoebae in the presence of various cysteine proteinase inhibitors (CPIs). It was found that broad range CPIs, which are membrane permeable and rapidly enter t...
متن کاملErratum. The Use of Anthropometric Measures for Cardiometabolic Risk Identification in a Rural African Population. Diabetes Care 2013;37:e64–e65
In the article listed above, there was an omission from the byline of author Dermot Maher. Dr. Maher’s name and affiliation (Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda) have been added to the online version of the article. Dr. Maher’s contributions to the manuscript also have been added to the Author Contributions section. Georgina A....
متن کاملAdditive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64
Potential new targets for antimalarial chemotherapy include parasite proteases, which are required for several cellular functions during the Plasmodium falciparum life cycle. Four new derivatives of N-alkyl and N-benzyl-1,10-phenanthroline have been synthesized. Those are (1)-N-methyl-1,10-phenanthrolinium sulfate, (1)-N-ethyl-1,10-phenanthrolinium sulfate, (1)-N-benzyl-1,10-phenanthrolinium ch...
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ژورنال
عنوان ژورنال: Arthropod Management Tests
سال: 2012
ISSN: 2155-9856
DOI: 10.4182/amt.2012.e64